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A total of 3 % of Lively compound is excreted in urine as unchanged active material. Tapentadol is additionally metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, which are more metabolised by conjugation. For that reason, Energetic compound metabolism mediated by cytochrome P450 procedu